Hair Follicular Stem Cells: The Bulge-Activation Hypothesis
نویسندگان
چکیده
منابع مشابه
Review Paper: Application of Hair Follicle Bulge Stem Cells in Wound Healing
Despite the significant advances in regenerative medicine, wound healing has remained a challenging clinical problem. Skin is the largest human organ with many vital functions; therefore, any damage to its normal structure should be treated as soon as possible. Easy access to skin stem cells has created a lot of excitement in therapeutic applications. “Cell therapy” is considered a novel method...
متن کاملHuman follicular stem cells: their presence in plucked hair and follicular cell culture.
BACKGROUND AND OBJECTIVES A considerable portion of the hair follicle remains attached to plucked hair and can be used for follicle cell culture. In this study we have phenotyped these cells in an attempt to identify the stem cell fraction. Reports in the literature have indicated that this cell population may be positive for cytokeratin (CK) 19. Because stem cells in general need to be protect...
متن کاملNotch/RBP-J Signaling Regulates Epidermis/Hair Fate Determination of Hair Follicular Stem Cells
Notch signaling is involved in the cell fate determination of various cell lineages. Notch interaction with its ligand induces the cleavage of its intracellular domain (IC), and the Notch IC translocates to the nucleus and binds to RBP-J to transactivate transcription of target genes. All four Notches in mammals bind to RBP-J to exert their transactivation activities. Notch is expressed in deve...
متن کاملHair Follicle Bulge Stem Cells Appear Dispensable for the Acute Phase of Wound Re‐epithelialization
The cutaneous healing response has evolved to occur rapidly, in order to minimize infection and to re-establish epithelial homeostasis. Rapid healing is achieved through complex coordination of multiple cell types, which importantly includes specific cell populations within the hair follicle (HF). Under physiological conditions, the epithelial compartments of HF and interfollicular epidermis re...
متن کاملLabel-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis.
Inconsistent with the view that hair follicle stem cells reside in the matrix area of the hair bulb, we found that label-retaining cells exist exclusively in the bulge area of the mouse hair follicle. The bulge consists of a subpopulation of outer root sheath cells located in the midportion of the follicle at the arrector pili muscle attachment site. Keratinocytes in the bulge area are relative...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1991
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12471959